[Application of allogenous dural membrane (brefotissue DM) in surgical treatment of retraction pockets of the tympanic membrane]. / Primenenie allogennoi tverdoi mozgovoi obolochki (brefotkan' tverdoi mozgovoi obolochki) pri khirurgicheskom lechenii retraktsionnykh karmanov barabannoi pereponki.

INTRODUCTION: The tactics of treating patients with retraction pockets of the tympanic membrane is still debatable. When choosing surgical treatment, preference is given to the removal of the retraction pocket with simultaneous reconstruction of the posterior-upper wall of the external auditory canal (retraction area) with a cartilage or fascial flap, autologous bone, or a combination of the above tissues. Considering the well-known negative aspects of the use of all the mentioned grafts, there is a need to find new types of tissues to strengthen the retraction pocket. For example, dura mater brefotissue has good plastic properties, resistance to infection, is easy to prepare, store, and is cheaper than many allografts. AIM: Evaluation of the possibility of using dura mater brefotissue in the surgical treatment of patients with retraction pockets of the tympanic membrane. MATERIALS AND METHODS: The study included 52 patients who underwent surgery to eliminate the retraction pocket. All of them were divided into 2 groups. In the first - the main (n=25) cartilage of the auricle was used to seal the relaxed part of the tympanic membrane, in the second - the control (n=27) applied tissue of the dura mater. After 1, 3, 6 and 12 months, to assess the result of the intervention, all patients underwent otomicroscopy, audiometry with the calculation of the average sound conduction index for speech frequencies. RESEARCH RESULTS: Fewer cases (4 patients out of 27) had difficulty in graft placement with the use of dura mater compared to the group where cartilage was used (9 patients out of 25). The average duration of graft placement was 8±0.5 minutes in the control group and 2±0.3 minutes in the main group. A stable morphological result was obtained in the group with the use of brefotissue in 26 patients (96%) and only in 20 patients (80%) with the use of cartilage. It is important to note that in the group with the use of brefotissue, in the early postoperative period, there was an increase in the air-bone interval, and 1 month after the operation, the average values increased by 10±0.5 dB. 12 months after the operation, the above parameters returned to preoperative. CONCLUSION: The conducted study indicates that the dura mater brefotissue, having sufficient strength, the convenience of forming a given shape and placing it in the desired position, can be successfully used in the surgical treatment of patients with retraction pockets of the tympanic membrane.

[Evaluation of the clinical efficacy of local antibacterial therapy in the treatment of acute bacterial rhinosinusitis].

AIM: To evaluate the clinical efficacy of Polydexa with phenylephrinum in the complex treatment of moderate acute bacterial rhinosinusitis. MATERIALS AND METHODS: The article presents the results of a clinical study of 100 patients with moderate acute bacterial rhinosinusitis 37 (37%) men, 63 (63%) women aged 15 to 53 years. The patients were randomized into 2 groups of 50 people each. In the study group, patients received systemic antibiotic therapy and a topical nasal spray of Polydexa with phenylephrinum. The control group received systemic antibacterial therapy and long-acting local decongestants. The evaluation criteria were statistically significant differences in clinical and laboratory parameters of the control and main groups. RESULTS AND CONCLUSION: The pronounced anti-inflammatory, antimicrobial effects of the drug were confirmed; conclusions were drawn about the clinical efficacy, tolerability, safety of Polydexa with phenylephrinum and allows to achieve complete resolution of the pathological process in more cases.

[Morphological and functional changes in the tympanic cavity after its filling with platelet-enriched plasma (an experimental study)]. / Morfologicheskie i funktsional'nye izmeneniia v barabannoi polosti posle zapolneniia ee obogashchennoi trombotsitami plazmoi (éksperimental'noe issledovanie).

This experimental study had the objective to estimate the functional state of the sound-conducting system of the middle ear and morphological changes in the tympanic cavity after its filling with platelet-enriched plasma (PEP) obtained by one-step centrifugation of the whole venous blood. The experiments were made on 6 pigs of the Large White breed. Tympanotomy performed under general anesthesia was followed by the introduction of a clot of platelet-enriched plasma into the tympanic cavity. The results of the study indicate that the ventilation function of the pharyngotympanic tube was fully preserved. The PEP clot was completely eliminated from the tympanic cavity within the first month after filling. Neither scars nor adhesions were recorded after the treatment with PEP. The study confirms the beneficial effect of using PEP for the support of the sound-conducting structures of the middle ear and stimulation of the regeneration processes after tympanoplasty.

[Application of platelet-enriched plasma for the prevention of cochleovestibular disorders associated with piston stapedoplasty].

The present study was designed to evaluate the influence of sealing the labyrinthine vestibule with platelet-enriched plasma (PEP) on the development of cochleovestibular complications following piston stapedoplasty. The platelet-rich plasma was prepared by single-step centrifugation of the whole venous blood. Analysis of the data obtained showed that the use of PEP for sealing the periprosthetic space after stapedoplasty reduces the risk of development of sensorineural hearing impairment compared with the application of fatty tissue for the same purpose or a freely positioned prosthesis. Moreover, the use of PEP decreases the probability of the development of tympanophonia and its intensity after piston stapedoplasty.

[The efficacy of sinuforte in the starting monotherapy of the patients presenting with acute rhinosinusitis].

The present randomized open study included 30 patients with acute suppurative rhinosinusitis. The efficacy of the treatment was estimated from the dynamics of the patients' subjective sensations and the objective assessment of clinical manifestations of the disease on days 1, 3, 5, and 7 after the onset of therapy. All the patients were prescribed treatment with sinuforte (one dose administered daily into each half of the nasal cavity at one and the same time). It was shown that monotherapy with sinuforte for the treatment of patients presenting with acute suppurative rhinosinusitis of moderate severity ensured the recovery in 73% of the cases.